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Science Student


Propranolol Decreases Fear Expression by Modulating Fear Memory Traces

Leal Santos S, Stackmann M, Muñoz Zamora A, Mastrodonato A, De Landri AV, Vaughan N, Chen BK, Lanio M, and Denny CA. (2021). Biol Psychiatry. 89(12):1150-1161 PMID: 33766406.

Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage

Hsieh C, Tsokas P, Grau-Perales A, Lesburguères E, Bukai J, Khanna K, Chorny J, Chung A, Jou C, Burghardt NS, Denny CA, Flores-Obando RE, Hartley BR, Rodríguez Valencia LM, Hernández AI, Bergold PJ, Cottrell JE, Alarcon JM, Fenton AA, and Sacktor TC. (2021) European Journal of Neuroscience. 54(8):6795-6814. PMID: 33540466.

Optogenetic reactivation of prefrontal social neural ensembles mimics social buffering of fear

Gutzeit VA, Ahuna K, Santos TL, Cunningham AM, Sadsad Rooney M, Muñoz Zamora A, Denny CA, and Donaldson ZR. (2020) 45:1068-1077. PMID: 32035426.

Identification and optogenetic manipulation of memory engrams in the hippocampus

Lacagnina AF, Brockway ET, Crovetti CR, Shue F, McCarty MJ, Sattler KP, Lim SC, Santos SL, Denny CA, and Drew MR. (2019) Nat Neurosci. 22:753-761. PMID: 30936555.

Optimization of immunolabeling and clearing techniques for indelibly labeled memory traces

Pavlova IP, Shipley SC, Lanio M, Hen R, and Denny CA*. (2018) Hippocampus. 28:523-535. PMID: 29663578.

Proximodistal heterogeneity of hippocampal CA3 pyramidal neuron intrinsic properties, connectivity and reactivation during memory recall

Sun Q, Sotayo A, Cazzulino AS, Snyder AM, Denny CA, and Siegelbaum SS. (2017) Neuron. 95:656-672. PMID: 28772124.

From Engrams to Pathologies of the Brain

Denny CA, Lebois E, and Ramirez S. (2017) Frontiers in Neural Circuits. 11:23. PMID: 28439228.

Improved specificity of hippocampal memory trace labeling

Cazzulino AS, Martinez R, Tomm NK, and Denny CA*. (2016) Hippocampus. 26: 752-762. PMID: 26662713.

The participation of cortical amygdala in innate, odor-driven behavior

Root CM, Denny CA, Hen R, and Axel R. (2014) Nature 515:269-273. PMID: 25383519

Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis

Denny CA, Kheirbek MA, Alba EL, Tanaka KF, Brachman RA, Laughman KB, Tomm NK, Turi GF, Losonczy A, and Hen R. (2014) Neuron 83:189-201. PMID: 24991962.

Science Student


Traumatic Brain Injury-Induced Fear Generalization in Mice Involves Hippocampal Memory Trace Dysfunction and Is Alleviated by (R,S)-Ketamine

McGowan JC, Ladner LR, Shubeck CX, Tapia J, LaGamma CT, Anqueira-González A, DeFrancesco A, Chen BK, Hunsberger HC, Sydnor EJ, Logan RW, Yu TS, Kernie SG, Denny CA. (2024) Biol Psychiatry. 95(1):15-26. PMID: 37423591.

Acute ( R,S)-Ketamine Administration Induces Sex-Specific Behavioral Effects in Adolescent but Not Aged Mice

Mastrodonato A, Pavlova I, Kee N, McGowan JC, Mann JJ, Denny CA. (2022) Front. Neurosci. 16:852010. PMID: 35527817

Fluoroethylnormemantine, a Novel NMDA Receptor Antagonist, for the Prevention and Treatment of Stress-Induced Maladaptive Behavior

Chen BK, Luna VM, Shannon ME, Hunsberger HC, Mastrodonato A, Stackmann M, McGowan JC, Rubinstenn G, and Denny CA*. (2021) Biol Psychiatry. 90(7):458-472. PMID: 34274107

Fluoroethylnormemantine, A Novel Derivative of Memantine, Facilitates Extinction Learning Without Sensorimotor Deficits

Chen BK, Le Pen G, Eckmier A, Rubinstenn G, Jay TM, and Denny CA. (2021) Int J Neuropsychopharmacol. 24:519-531. PMID: 33631001.

Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine

Chen BK, Luna VM, LaGamma CT, Xu X, Deng SX, Suckow RF, Cooper TB, Shah A, Brachman RA, Mendez-David I, David DJ, Gardier AM, Landry DW, and Denny CA*. (2020) Neuropsychopharmacology. 45:1545-1556. PMID: 32417852.

Prophylactic (R,S)-ketamine selectively protects against inflammatory stressors

Mastrodonato A, Cohensedgh O, LaGamma CT, McGowan JC, Hunsberger HC, and Denny CA*. (2019) Behav Brain Res. 378:112238. PMID: 31563463.

Antidepressant but Not Prophylactic Ketamine Administration Alters Calretinin and Calbindin Expression in the Ventral Hippocampus

LaGamma CT, Tang W, Morgan A, McGowan JC, Brachman RA, and Denny CA*. (2018) Front Mol Neurosci. 11: 404. PMID: 30459554.

Ventral CA3 Activation Mediates Prophylactic Ketamine Efficacy Against Stress-Induced Depressive-like Behavior

Mastrodonato A, Martinez R, Pavlova IP, LaGamma CT, Brachman RA, Robison AJ, and Denny CA*. (2018) Biol Psychiatry. 84:846-856. PMID: 29615190.

Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects

Pham TH, Defaix C, Xu X, Deng S-X, Fabresse N, Alvarez J-C, Landry DW, Brachman RA, Denny CA*, and Gardier AM*. (2018) Biol Psychiatry. 84:e3-e6. PMID: 29174592.

Prophylactic Ketamine Attenuates Learned Fear

McGowan JC, LaGamma CT, Lim SC, Tsitsiklis M, Neria Y, Brachman RA, and Denny CA*. (2017) Neuropsychopharmacology. 42: 1577-1589. PMID: 28128336.

Ketamine as a Prophylactic Against Stress-Induced Depressive-like Behavior

Brachman RA, McGowan JC, Perusini JN, Lim SC, Pham TH, Faye C, Gardier AM, Mendez-David I, David DJ, Hen R, and Denny CA*. (2016) Biol Psychiatry. 79:776-786. PMID: 26037911.

An Animal Model of a Behavioral Intervention For Depression

Pollak DD, Monje FJ, Zuckerman L, Denny CA, Drew MR, and Kandel ER. (2008) Neuron 60:149-161. PMID: 18940595.

Image by Robina Weermeijer


Molecular and Cellular Underpinnings of Age-Related Memory Loss

Kosmidis S, Denny CA, Dranovsky A, and Skoulakis EM. (2021) Frontiers in Cell and Developmental Biology. 9:743187. PMID:34490280

Divergence in the metabolome between natural aging and Alzheimer's disease

Hunsberger HC, Greenwood BP, Tolstikov V, Narain NR, Kiebish MA, and Denny CA. (2020) Sci Reports 10:12171. PMID: 32699218.

RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss

Kosmidis S, Polyzos A, Harvey L, Youssef M, Denny CA, Dranovsky A, and Kandel ER. (2018)  Cell Reports. 25: 959-973. PMID: 30355501.

Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population

Faye C#, McGowan JC#, Denny CA*, and David DJ*. (2018) Current Neuropharmacology. 16:234-270. PMID: 28820053.

Optogenetic stimulation of dentate gyrus engrams restores memory in Alzheimer's disease mice

Perusini JN, Cajigas SA, Cohensedgh O, Lim SC, Pavlova IP, Donaldson ZR, and Denny CA*. (2017) Hippocampus. 27:1110-1122. PMID: 28667669.

Science Student


Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus

Luna VM, Anacker C, Burghardt NS, Khandaker H, Andreu V, Millette A, Leary P, Ravenelle R, Jimenez JC, Mastrodonato A, Denny CA, Fenton AA, Scharfman HE, and Hen R. (2019) Science. 364:578-583. PMID: 31073064.

Outsmarting (and outrunning) nature’s harsh decree

Drew MR and Denny CA*. (2018) Nature Neuroscience. 21: 1141-1142. PMID: 30127426.

Olfactory memory is enhanced in mice exposed to extremely low-frequency electromagnetic fields via Wnt/β-catenin dependent modulation of subventricular zone neurogenesis

Mastrodonato A, Barbati SA, Leone L, Colussi C, Gironi K, Rinaudo M, Denny CA, and Grassi C. (2018) Scientific Reports. 8: 262.

Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding

Danielson N, Kaifosh P, Zaremba JD, Lovett-Barron M, Tsai J, Denny CA, Balough EM, Goldberg A, Drew LJ, Losonczy A, Hen R, and Kheirbek MA. (2016) Neuron. 90: 101-112. PMID: 26971949.

Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons

Drew LJ, Kheirbek MA, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, and Hen R. (2016) Hippocampus. 26: 763-778. PMID: 26662922.

Regulation of hippocampal memory traces by neurogenesis

Anacker C, Denny CA, and Hen R. (2015) Neurogenesis (Austin). 17: e1025180. PMID: 27604158.

Suppression of adult neurogenesis increases the acute effects of kainic acid

Iyengar SS, LaFrancois JJ, Friedman D, Drew LJ, Denny CA, Burghardt NS, Wu MV, Hsieh J, Hen R, and Scharfman HE. (2015) Exp Neurol. 265: 135-149. PMID: 25476494.

Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis

Denny CA, Kheirbek MA, Alba EL, Tanaka KF, Brachman RA, Laughman KB, Tomm NK, Turi GF, Losonczy A, and Hen R. (2014) Neuron 83: 189-201. PMID: 24991962.

4–6 week old adult-born hippocampal neurons influence novelty-evoked exploration and contextual fear conditioning

Denny CA, Burghardt NS, Schacter DM, Hen R, and Drew MR. (2012) Hippocampus. 22: 1188-1201. PMID: 21739523.

Arrest of adult hippocampal neurogenesis in mice impairs single- but not multiple-trial contextual fear conditioning

Drew MR, Denny CA, and Hen R. (2010) Behav Neurosci. 124: 446-454. PMID: 20695644.


Laboratory Scientist

Prophylactic efficacy of 5-HT4R agonists against stress

Chen BK, Mendez-David I, Luna VM, Faye C, Gardier AM, David DJ, and Denny CA*. (2020) 45:542-552. PMID: 31600767.

Rapid Anxiolytic Effects of RS67333, a Serotonin Type 4 Receptor Agonist, and Diazepam, a Benzodiazepine, Are Mediated by Projections From the Prefrontal Cortex to the Dorsal Raphe Nucleus

Faye C, Hen R, Guiard BP, Denny CA, Gardier AM, Mendez-David I, and David DJ. (2020) Biol Psychiatry. 87:514-525.  PMID: 31623825.

Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mic

Chen CV, Nwakeze CL, Denny CA, O’Keeffe S, Rieger M, Mountoufaris G, Kirner A, Dougherty JD, Hen R, Wu Q, and Maniatis T. (2017) Science. 356: 406-411. PMID: 28450636.

Science Student


3D microphotonic probe for high resolution deep tissue imaging

Tadayon MA, Chaitanya S, Martyniuk KM, McGowan JC, Roberts SP, Denny CA, and Lipson M. (2019) Optics Express. 27:22352-22362. PMID:31510530.

Microphotonic needle for minimally invasive endoscopic imaging with sub-cellular resolution

Tadayon MA, Pavlova I, Maryniuk KM, Mohanty A, Roberts SP, Barbosa F, Denny CA, and Lipson M. (2018) Scientific Reports. 8: 10756. PMID: 30018316.

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